ESMO Sarcoma & Rare Cancers is a new annual congress which will take place for the first time in Lugano, Switzerland. This highly specialised meeting will integrate contents from both the former ESMO Sarcoma GIST & Symposium and the ESO-ESMO-RCE Clinical Update on Rare Adult Solid Cancers, bringing together the most brilliant medical minds working on these tumour types. The ESMO Sarcoma & Rare Cancers Congress will constitute a unique occasion for the international rare cancers community to network and collaborate, featuring discussions with key opinion leaders in these sub-entities. The congress will focus on the heterogeneous cohort of rare histologies across organ sites, and on their common themes: from diagnosis and pathology, to multidisciplinary expert management, from targeted therapies and precision medicine, to research, methodological challenges and policy.